While the human heart has a very limited capacity to regenerate itself, amphibians, such as salamanders, can easily regenerate their heart muscles.

In a study by researchers at the Karolinska Institute, Sweden, they found that the outermost layer of a salamander’s heart, called the epicardium, can act as a source of cardiac muscle cells to regenerate the heart.

This is an important discovery, as similar epicardial cells also exist in the human heart.

“This work establishes a new cellular and molecular paradigm for adult heart muscle regeneration and could offer new hope to millions of patients waiting for a heart transplant,” said Professor Ken Chien, co-author of the study.

Heart diseases are the leading cause of death worldwide.

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