As the end of the year approaches, we reflect on the remarkable scientific discoveries made in 2025 across various fields, ensuring that all methodologies, including the use of animals, are integrated into the most contemporary biomedical research. 

Researchers in the US created a detailed atlas showing how astrocytes, star-shaped support cells in the brain, differ across brain regions, animal species and life stages. The atlas will help to understand how these cells influence brain development, function and disease.

A study in the Netherlands has discovered that corticosteroids, widely used anti-inflammatory drugs, may prolong the effect of hormone therapy for breast cancer in mice.

Researchers in France have developed a vaccine that protects mice against anaphylaxis, a severe and life-threatening allergic reaction. This work could inform the development of new treatments for people with severe allergies.

Research from the US shows that artificial intelligence (AI) can accurately predict how proteins interact with one another.

Research institutions in Spain continue to strengthen their commitment to openness about animal research, according to the latest evaluation report covering 2024 and produced by the European Animal Research Association (EARA).

A study in the US used pigs as a model for a common liver complication caused by intravenous feeding in premature babies. 

A study from South Korea has discovered that astrocytes, a type of brain cell that helps maintain brain internal balance, play an active role in nicotine addiction in rats.  

The second Portuguese Open Week on Animal Research (2–5 December) brought institutions across Portugal together to promote transparency and public understanding of the use of animals in biomedical research. The initiative is part of the Portuguese Transparency Agreement and supported by the European Animal Research Association (EARA). 

Research from the US shows that a new lymph-node-on-a-chip can replicate age-dependent immune responses to cancer vaccines, providing a more accurate testing platform.