The principle of the 3Rs (Replace, Reduce, Refine) was introduced in 1959 and establishes the accepted standards for research with animals.
The 3Rs are part of the everyday practice of the European biomedical sector and are an integral part of both national and international laws that regulate the use of animals in scientific procedures.
The 3Rs are:
Replacement - Methods that prevent or help replace the use of animals
Methods that help reduce the number of animals used in experiments
Refinement - Methods that help minimize any pain or distress and improve animal welfare.
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