Researchers at EARA member the University of Padova, Italy, have found a potential target for early treatment of kidney inflammation caused by lupus.
Lupus - an autoimmune disease - occurs when the body’s immune system attacks its own tissues and organs. One of the most sever organ manifestations of this condition is lupus nephritis, a type of kidney disease that could lead to kidney failure.
The team used mice to understand the role of Pentraxin3 (PTX3) – a molecule known to be unbalanced in human lupus.
They found that mice immunised with PTX3 developed a protective immunity, preventing them from developing overt lupus nephritis, and improving overall survival.
“Animal research allows us to make crucial advances when dealing with rarer conditions in which targeted treatments - instead of lifelong dependence on drugs - are paramount for a better outcome in terms of both survival and the quality of life of our patients.”
Mariele Gatto, MD, PhD, Unit of Rheumatology, Padova University