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Imaging zebrafish for ALS research

Updated: Feb 9, 2021

Scientists at the Institut National de la Recherche Scientifique, Quebec, Canada, have created an imaging tool to visualise the motor deficits of ALS (or MND) in zebrafish.

The team tracked the position of animals in 3D - using a technology called DECALF - to study the escape behaviour of zebrafish with ALS-like symptoms.

The findings, published in the journal Optica, revealed that animal models of ALS had slow responses and limited movement when compared to normal zebrafish.

“Using this innovative imaging approach, we could learn about what is happening in the neural system in normal and disease states in a non-invasive manner,” said Professor Kessen Patten of INRS.


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