Alzheimer's new treatment target

Updated: Jun 26

Scientists in Portugal have found a genetic sequence in mice that could be a new treatment target for Alzheimer’s disease.

The team from the Center for Neuroscience and Cell Biology (CNC), Coimbra, in collaboration with Liverpool University, UK, identified a microRNA - little genetic sequences with a regulatory role in our cells – with beneficial effects in animal models of Alzheimer’s.

Using only female mice, it was shown that animals expressing microRNA-31 had decreased levels of the toxic elements, characteristic of this disease, in the region of the brain responsible for memory.

Ana Luísa Cardoso, of CNC, explained the importance of using female animals in this study given that Alzheimer’s is much more prevalent in women, while the majority of the studies have been carried out in male animals.

Next steps might mean studies of other roles of the microRNA in different animal models which could be more easily compared to humans.

Copyright © 2019 European Animal Research Association, All rights reserved.

European Animal Research Association 

London Office

Abbey House, 74-76 St John Street
London EC1M 4DZ
Tel: +44 (0)20 3675 1245

Brussels Office
52 Rue Marie de Bourgogne, 1st Floor
1000 Brussels,


  • Twitter
  • Facebook
  • LinkedIn Social Icon
  • Facebook Social Icon
  • Twitter Social Icon
  • LinkedIn Social Icon